silymarin 140 mg price

Silymarin, Supply Chains, and Real-World Specs: What Buyers Should Know If you source botanicals, you’ve heard the buzz. Milk Thistle Extract Silymarin Powder Liver Protection Chinese Plant Extract is quietly becoming a staple in liver-health SKUs and, interestingly, in functional beverage premixes. To be honest, the demand spike feels cyclical—regulatory clarity improves, brands reformulate, and procurement teams chase consistent assays. From our visits to Zhengding (Hebei), the supply story is pretty straightforward: quality seeds, careful solvent handling, and obsessive HPLC fingerprints. The product originates from Building 23B1, No.2 Yuanboyuan St., Zhengding Area of China (Hebei) Pilot Free Trade Zone—an address you’ll now find on many import docs, which helps with traceability. Product snapshot and typical specs Item Specification (≈, real-world may vary) Method/Standard Botanical / Part Silybum marianum (L.) Gaertn, Seed Macroscopic ID Extract solvent Acetone GC residual solvent check (ICH Q3C) Silymarin (total) 50%, 60%, 70%, 80% (HPLC/UV options) HPLC-UV (silybin A/B, isosilybin, silydianin, silychristin) Appearance Light yellow to brown fine powder Visual Loss on drying ≤5.0% EP/ChP Residual acetone Typically ≤500 ppm (limit per ICH Class 3 ≈ 5000 ppm) GC Heavy metals Meets ICH Q3D ICP-MS Microbiological TPC ≤1,000 cfu/g; Yeast&Mold ≤100; Pathogens: absent Plate count / ISO Packaging / Shelf life 25 kg fiber drum; 24 months sealed, cool & dry COA/real-time stability Compliance tags Non GMO, BSE/TSE Free, Non Irridiation, Allergen Free Supplier declaration + third-party tests Process flow (simplified) Qualified seeds → cleaning → milling Acetone extraction under GMP Filtration → concentration → refining (reduce non-actives) Standardization to target assay Drying (vacuum) → milling → sieving QC: ID (HPTLC), assay (HPLC), residual solvent (GC), microbes Packing with full traceability (lot, harvest, solvent batch) Retention samples + stability trending Where it’s used (and why) Brands lean on Milk Thistle Extract Silymarin Powder Liver Protection Chinese Plant Extract for liver-health capsules, tablet blends, effervescents, gummies (yes, really), and RTD beverage sachets. Pet supplements and even cosmetics (antioxidant claims) show up, though stability in water systems needs thought—use chelators and protect from light. Vendor comparison at a glance Factor Finutra (Zhengding) Generic Trader Spot Broker Assay options 50–80% (HPLC/UV) Mostly 50–60% Varies, limited traceability Lead time ≈7–15 days ≈15–25 days 2–5 days QC transparency Full COA + HPLC chromatograms COA only Basic COA Certs (typical) ISO/HACCP/GMP—on request Partial Unclear Test data (example lot, 70% target) Silymarin total (HPLC): 70.8% Silybin A+B: 33.2% Residual acetone: 210 ppm LOD: 3.1%; TPC: 320 cfu/g; Pathogens: negative Customization and industry trends Requests we keep seeing: tighter residual-solvent limits for beverages, low-flavor variants, and higher silybin ratios for “premium” lines. Many customers say the 60% HPLC grade is the sweet spot for cost vs. label claim. Interestingly, sports nutrition is piloting stackable “liver support” sachets—surprisingly sticky category. Two quick cases US brand reformulation: switched to 70% HPLC from UV 80% to avoid over-coloring gummies; complaints dropped in 1 cycle. EU beverage pre-mix: custom grind (D90 ≈ 180 μm) improved dispersibility; stability at 25°C/60% RH held assay for 6 months. Note: This material supports liver health in general wellness contexts; not medical advice or a treatment claim. Always verify regional compliance. Standards and references buyers actually use European Pharmacopoeia: Milk thistle dry extract, refined and standardised (assay by HPLC) Chinese Pharmacopoeia: Silymarin monograph (ID/assay) ICH Q3C/Q3D for residual solvents and elemental impurities For formal quotes or COAs, ask for full chromatograms and batch traceability tied to the lot from Zhengding. It seems basic, but that’s where weak supply breaks. Authoritative citations NCCIH: Milk Thistle (overview of use and safety) NIH LiverTox: Silymarin (Milk Thistle) profile European Pharmacopoeia: Milk thistle dry extract, refined and standardised Chinese Pharmacopoeia Commission (ChP references for Silymarin)